"An Anglo-American Alliance: A Serio-Comic Romance and Forecast of the Future" by Gregory Casparian is a novel published in 1906. Set in 1960, it envisions a world where two upper-class women from Britain and America meet at a ladies' seminary and develop a secret romance. Their relationship takes an unexpected turn when one undergoes surgical transformation to become a man. This obscure work has been called the first lesbian science fiction novel and features what may be science fiction's first transgender hero. (This is an automatically generated summary.)